Journal of Diabetes and Metabolic Disorders 2006. 5(0):160-.

EFFECTS OF PERSIAN WALNUT (LAVASANATREGION) OIL EXTRACT ON LIPID PROFILE IN ANIMAL MODEL (HYPERCHOLESTEROLEMIC MALE RATS).
Javad Zavar Reza, Mahmoud Dousti, Sadigheh Soleimani, Farzad Asadi Jamnani, Bardia Farzamfar, Shahrnaz Aria Barzin, Ali Jalilian

Abstract


Background: Experimental studies have shown that walnut (Juglans regia) intake decreases the risk of coronary heart disease (CHD). Walnut decreases the levels of atherogenic lipids such as TG, LDL-C and VLDL-C. Mainly the effect is induced via w3- Poly Unsaturated Fatty Acids (w3-PUFA). Walnuts are a rich source of these fatty acids, especially a-Linolenic acid (C18:3; 9, 12, 15).


Methods: We assigned 20 hypercholesterolemic male Rats (200-250g) to four groups, and fed with four diet concentration of oil extract Persian walnuts(J. regia)(Lavasanate) (w/w ) as complementary diet: control group (0% oil extract) and cases 5%(1g oil extract/1g weight/1 day) ,7.5%(1.5g oil extract/1g weight/1 day),10%(1g oil extract/1g weight/1 day) for eight weeks.


Results:  Results revealed there is a positive effect on the decreasing of TG(14%) ,TC(7.8%) , LDL-C(11%),VLDL-C(12%) serum concentrations, with increasing consumption of oil  extract Persian walnuts (5% ,7.5% and 10%).


Conclusion: In view of the positive effect of oil extract Persian walnuts (J. regia) consumption on decrease serum concentration of TG, TC, LDL-C and VLDL-C known as atherogenic lipids and lipoproteins, it may be suggested as a CHD protective dietary supplement.


Keywords


Oil extract of Persian walnut, Lipid profile, Coronary heart disease, Hyper-cholestrolemic Male Rat,

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