Journal of Diabetes and Metabolic Disorders 2010. 9( ):7-.

Osteocalcin and cross laps Status among Women with Gestational Diabetes Mellitus during Pregnancy
Hossein-nezhad A, Maghbooli Zh, Mirzaei Kh, Rahmani M, Larijani B


Background: The aim of the study was to compare the bone turnover in healthy pregnant women and patients with Gestational Diabetes Mellitus (GDM).
Methods: A cross-sectional study was conducted on 695 pregnant women referred to five teaching hospital clinics. Universal screening was performed with Glucose Challenge Test (GCT)-50 g. Those with plasma glucose levels ≥7.2 mmol/L were diagnosed as GDM if they had an impaired GTT-100 g based on Carpenter and Coustan criteria. The levels of insulin and C-peptide were measured during OGTT-100 g test. The homeostasis model assessment index (HOMA) equation was used as the insulin resistance index. The concentrations of Osteocalcin, cross laps, and calcium were also measured.
Results: There was a significant difference in Osteocalcin and Crosslaps levels between GDM and normal groups. Concerning bone markers and insulin resistance, after adjusting for BMI and age, in regression model the HOMA index revealed significant relation with serum levels of Crosslaps (P= 0.03, β = 0.16).
Conclusion: Our study showed a higher bone turnover in GDM patients during pregnancy. Specially increased bone resorption which was independently correlated with GDM may propose common defective pathways may contribute to GDM and bone loss pathogenesis.

Keywords: Gestational Diabetes Mellitus, Bone Turnover, Osteocalcin, Crosslap


Gestational Diabetes Mellitus, Bone Turnover, Osteocalcin, Crosslaps,

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