A 3-Year-Old Boy with Severe Obesity and Pseudoacromegaly; Short course treatment with OrlistatTM

Abstract

Specific syndromes and single-gene defects are rare causes of obesity, accounting for less than one percent of childhood obesity. Most endocrine and genetic causes of obesity are associated with short stature. The purpose of this paper was clinically and biochemically describe a toddler with insulin mediated pseudoacromegaly and in addition, to examine the response to pharmacologic therapy. The patient was a 3-year-old boy with severe obesity, pseudoacromegaly, Blount disease and acanthosis nigricans diagnosed as insulin resistance syndrome according to clinical and biochemical findings. A trial for measuring the effect of Orlistat^TM on weight gain and body mass index was done.