Journal of Diabetes and Metabolic Disorders 2010. 9( ):19-.

Serum Vitamin D Concentration in Pandemic 2009 H1N1 Influenza Infected Patients
Khalili H, Nasiripour S, Etminiani-Esfahani M


Background: Recently, immunomodulatory effect of vitamin D was documented. It was proposed that serum level of vitamin D in some populations including patients with asthma, cystic fibrosis, chronic obstructive pulmonary disease (COPD), tuberculosis and respiratory infections is lower than normal. We have evaluated serum vitamin D concentration in H1N1 infected patients.
Methods: Fifty-two patients with documented H1N1 influenza were enrolled the study during pandemic 2009 flu. Patients' demographic data was recorded and one venous blood sample (3 ml) was collected from each patient at same time a day (at morning). Serum 25 (OH) D concentrations was measured by Chemiluminescence method.
Results: Median (interquartiles 25-75) serum 25 (OH) D concentrations in the studied population was 26.62 (13.85-45.86) nmol/l. In men and women enrolled in the study, medians (interquartiles 25-75) of serum 25(OH) D were 28.95 (21.10-44.55) and 16.72 (10.48-98.34), respectively. Serum vitamin D concentration was higher in women than men, but it was not statistically significant.
Conclusion: Based on vitamin D deficiency definition [serum 25(OH) D levels less than 35 nmol/l], 60.8% of the Iranian H1N1 infected patients had vitamin D deficiency.


Vitamin D, Pandemic 2009 flu, H1N1 influenza,

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