Journal of Diabetes and Metabolic Disorders 2004. 3(0):52-.

PREVALENCE OF THYROID AUTO ANTIBODIES IN DIABETIC CHILDREN AND ADOLESCENTS IN MASHHAD.
Rahim VAKILI, Mahmood MAHMOODI, Ali GHASEMI

Abstract


Background: Diabetes mellitus is the most common endocrine-metabolic disorder in childhood and adolescence. As many as one in five insulin-dependent diabetics may have thyroid antibodies in their serum; the prevalence is 2-20 times greater than that observed in general populations.


Methods: It this study we measured Tpo-ab, Tg-ab, TSH and HbA1C in 48 children and adolescents with diabetes and compared it with a control group that matched for sex and age. Clinical data including sex, age at onset and duration of diabetes, family history and sign and symptom of thyroid disease and goiter were recorded. Statistical analysis was made using SPSS soft wear.


Results: In diabetic group 12 patients had positive thyroid auto antibodies; Tg-ab was positive in ten and Tp-ab was positive in nine and both were positive in seven patients. The prevalence of thyroid antibodies in our study was 25% and in control group no one had thyroid antibodies (P=0.006). Among 12 patients with autoimmune thyroid disorder, three had hypothyroidism.


Conclusion: The prevalence of autoimmune thyroid disorder was not influenced by the sex, age, duration of diabetes and HbA1C. In conclusion about one-fourth of our diabetic patients had thyroid antibodies, and yearly routine determinations of thyroid antibodies are recommended.


Keywords


Diabetes type 1, Hypothyroidism, Thyroid antibody ,

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