Journal of Diabetes and Metabolic Disorders 2004. 3(0):54-.

STUDY OF CORRELATION BETWEEN INSULLIN-LIKE GROWTH FACTOR-I AND GLYCOSYLATED HEMOGLOBIN IN TYPE 1 DIABETES.
Nosratollah ZARGHAMI, Radina ESHTIAGHI, Ali KHOSROWBEYGI, Dian DAYER, Jamal HALLAJ

Abstract


Introduction: Diabetes is a common endocrine disease and complications such as retinopathy, nephropathy and neuropathy are major stimuli for enhancing efforts on controlling it using biomarkers. At present, glycosylated hemoglobin (HbA1c) is used for monitoring the long term control of glucose levels in diabetic patients. But due to the lack of availability of a standard range, recent findings suggest that insulin-like growth factor-I (IGF-I) may be used as a standard biomarker for monitoring blood glucose levels in diabetic patients. The aim of this study was to examine the correlation between IGF-I and HbA1c in Type 1 diabetes.


Methods: We designed a cross-sectional case-control study. The study composed of 26 newly diagnosed patients with Type 1 diabetes (15 male and 11 female; mean age, 23.7±9.1 years) and 26 healthy controls (9 male and 17 female; mean age, 24.1±4.4 years). We measured the concentrations of fasting plasma glucose (FPG), HbA1C, IGF-I and IGF-binding protein-3 (IGFBP-3) in both groups. FPG was measured by enzymatic glucose oxidase method and the colorimetric method was used to measure HbA1C. Determination of total serum levels of IGF-I and IGFBP-3 were carried out using immunoassay methods. P-value<0.05 was considered as statistically significant.


Results: The mean value of IGF-I concentration in type 1 diabetics was significantly lower than controls (p< 0.05). A reverse correlation was observed between IGF-I and HbA1c.


Conclusion: It is speculated that based on this findings, when diabetes is poorly controlled, levels of FPG and HbA1c increase while level of IGF-I decreases. Our study also showed a significant correlation between IGF-I and HbA1c. Therefore, IGF-I could be indirectly used as a biomarker for controlling glucose levels in diabetes.


Keywords


IGF-І, HbA1c, FPG, Type 1 diabetes,

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