Journal of Diabetes and Metabolic Disorders 2004. 3(0):56-.

PREVALENCE OF HELICOBACTER PYLORI INFECTION IN TYPE 1 DIABETIC CHILDREN REFERRING TO ISFAHAN ENDOCRINE & METABOLISM RESEARCH CENTER.
Behzad SHAMS, Mahin HASHEMIPOUR, Sayed Hossein SAADAT, Sayed Mohammad Hasan EMAMI, Zahra ABDE-YAZDAN, Khosrow KHATIBI, Sasan HAGHIGHI, Silva HOVSEPIAN, Akbar HASSAN-ZADEH

Abstract


Background: An increased prevalence of Helicobacter pylori infection (H.P) is common in diabetic patients, due to the presence of miscellaneous predisposing factors. In this study, the prevalence of H.P infection has been investigated in type 1 diabetic children.


Methods: In a cross-sectional study, anti H.P antibody (IgG) was measured in 75 type 1 diabetic patients (aged 2-18 years) and the results were compared with that of 75 healthy children matched for age, sex and socio-economic status. In seropositive diabetic patients with gastrointestinal (GI) symptoms, gastrodeoudenoscopy was performed to establish the diagnosis.


Results: Seropositivity for H.P was detected in 22.7% of diabetic patients, as compared to 17.3% in control group (P>0.05). No significant difference was observed between seropositive and seronegative diabetic groups regarding age, sex, age at onset of diabetes, number of outpatient visits during the last 6 months, HbA1c and insulin requirements. Gastrointestinal symptoms were more prevalent in diabetic children in comparison with healthy subjects but the prevalence of GI complaints did not differ significantly between seropositive and seronegative diabetic groups.


Conclusion:  Results show that type 1 diabetes is not associated with an increased risk for


Helicobacter pylori infection, although further studies are required to investigate the impact of treatment for H.P infection on glycemic control in diabetic children.


Keywords


Type 1 Diabetes, Helicobacter Pylori, Prevalence, Children,

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