Journal of Diabetes and Metabolic Disorders 2004. 4(0):104-.

COMPARISON OF EFFECTIVENESS OF LOVASTATIN AND GEMFIBROZIL ON HDL-C LEVEL IN DIABETIC TYPE 2 PATIENTS
Farzad Najafipour, Mehri A.Koukhi, Kazem Ghodousi, Masoumeh Zareizadeh

Abstract


Background: Diabetes mellitus is the most common human metabolic disease. Chronic hyperglycemia and carbohydrate metabolism disorder accompany with plasma lipid and lipoprotein disorder. Cardiovascular disease is one of the macro vascular complications of diabetes type 2 which leads to high morbidity and mortality. Dyslipidemia is one of the major risk factors of cardiovascular diseases in diabetic patients. High TG and low HDL-C levels are the most prevalent type of dyslipidemia. Low levels of HDL-c considered as a risk factor for cardiovascular diseases.


Methods:  In this study 40 type 2 diabetic patients (13 male - 27 female) were included.  Lovastatin   and  Gemfibrozil   were recommended   separately   for 2 months and HDL-C were measured at the baseline and after taking drugs. In all patients BS, TG and TC at the baseline before and after these drugs were normal and so were not any change in their diet. Laboratorial   findings   gathered   and analyzed. The relationship between increase level of HDL and decrease of TC with taking   Lovastatin   and Gemfibrozil were studied.


Results: The  averages  of  TC  and  HDL-C before taking drug as linear were 36.5mg/dl and  174.56 mg/dl  and  after   taking   Lovastatin  as   linear  were  43.3 mg/dl  and   150.44 mg/dl. The average of TC and HDL-C after taking Gemfibrozil were 43.33mg/dl and 146.36mg/dl. 18.54 % increase in HDL-C and 13.82% decrease in TC were seen with Lovastatin; and 18.54% increase in HDL-C and 16.05% decrease in TC were found with Gemfibrozil.


Conclusion:  In  this  study  no  difference  was  observed  between  the  effect of Lovastatin   and   Gemfibrozil  in  increase  of  HDL-C (P=0.449). Also there was no difference  between  the  effect  of  Lovastatin   and  Gemfibrozil  in  decrease  of TC (P=0.992).  The  increase  of  HDL-C  after  taking  Lovastatin  had   relation with  sex  and HDL-C increased in females (P=0.006); Also the increase of HDL-C after taking Gemfibrozil had relation with sex and females had more affected (P=0.035).


Keywords


Diabetes mellitus type 2, HDL-C, Gemfibrozil, Lovastatin,

Refbacks

  • There are currently no refbacks.