EFFECTS OF PERSIAN WALNUT (LAVASANATREGION) OIL EXTRACT ON LIPID PROFILE IN ANIMAL MODEL (HYPERCHOLESTEROLEMIC MALE RATS).

Abstract

Background: Experimental studies have shown that walnut (Juglans regia) intake decreases the risk of coronary heart disease (CHD). Walnut decreases the levels of atherogenic lipids such as TG, LDL-C and VLDL-C. Mainly the effect is induced via w3- Poly Unsaturated Fatty Acids (w3-PUFA). Walnuts are a rich source of these fatty acids, especially a-Linolenic acid (C18:3; 9, 12, 15).

Methods: We assigned 20 hypercholesterolemic male Rats (200-250g) to four groups, and fed with four diet concentration of oil extract Persian walnuts(J. regia)(Lavasanate) (w/w ) as complementary diet: control group (0% oil extract) and cases 5%(1g oil extract/1g weight/1 day) ,7.5%(1.5g oil extract/1g weight/1 day),10%(1g oil extract/1g weight/1 day) for eight weeks.

Results:  Results revealed there is a positive effect on the decreasing of TG(14%) ,TC(7.8%) , LDL-C(11%),VLDL-C(12%) serum concentrations, with increasing consumption of oil  extract Persian walnuts (5% ,7.5% and 10%).

Conclusion: In view of the positive effect of oil extract Persian walnuts (J. regia) consumption on decrease serum concentration of TG, TC, LDL-C and VLDL-C known as atherogenic lipids and lipoproteins, it may be suggested as a CHD protective dietary supplement.