Journal of Diabetes and Metabolic Disorders 2002. 1(1):51-57.

ANTINOCICEPTIVE EFFECT OF BACLOFEN IN ALLOXAN-INDUCED DIABETIC MICE.
Hossein Hosseinzadeh, Farid Ilami

Abstract


Objective: To evaluate the effect of hyperglycemia on the antinociceptive activity of baclofen, a GABAB agonist, in mice.


methods: We examined the antinociceptive effect of baclofen (2.5-7.5mg/kg injected intraperitoneally) in alloxan-induced mice using the hot-plate and tail-flick tests, both thermal tests.


results: Baclofen produced a dose-dependent inhibition of hot-plate response in both normoglycemic and diabetic mice. The antinociceptive activity of baclofen was slightly reduced in diabetic mice. In comparison, the antinociceptive activity of morphine (10mg/kg), used as control, was significantly reduced in diabetic mice.


conclusion: Our results show that hyperglycemia reduces the antinociceptive action of baclofen less than it does that of morphine.


Keywords


baclofen, hyperglycemia, antinociceptive activity, GABA, morphine,

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