Journal of Diabetes and Metabolic Disorders 2007. 6(0):4-.

THE EFFECT OF L – CARNITINE ON SERUM NITRIC OXIDE LEVEL AND ANGIOTENSIN CONVERTING ENZYME ACTIVITY IN STZ – INDUCED DIABETIC AND NORMAL RATS.
Ali mohammad Sharifi, Maryam Ghaderpanahi, Seyed Ziaedin Hosseini Mazhari

Abstract


Background: Cardiovascular disease including hypertension are complications of long-standing diabetes. A few Studies had shown the positive effects of L-carnitine on hypertension. In this study, the possible effects of L-carnitne on nitric oxide (NO) levels and angiotensin-converting enzyme (ACE) activity in serum as well as systolic blood pressure (SBP) in diabetic and normal rats were studied.


Methods: In this study forty rats were used in four groups including non-treated control (C), L-carnitne treated control (CT), diabetic (D) and L-carnitne treated diabetic (DT). Diabetes was induced in rats by injection of stereptozotosin. Both of C & D groups had a free access to food and water and CT & DT groups were received daily dose of L-carnation in drinking water. At the end of 12 weeks SBP, serum NO and ACE activity were measured.


Results: Systolic blood pressure was significantly decreased in DT group compared to D group. Serum ACE activity was also significantly decreased in DT group compared to D group and the serum NO levelswere significantly increased in DT & CT groups compared to D & C groups respectively.


Conclusion: Finally it could be concluded that L-carnitine may reduce SBP in diabetic rats via elevation of serum NO levels and reduction of serum ACE activity.


Keywords


L-carnitine, Diabetes, Hypertension, Nitric Oxide, Angiotensin Converting Enzyme ,

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