Insulin Buccal Spray (Oral-Lyn) efficacy in Type 1 Diabetes

Abstract

Background: To determine efficacy and side effects of oral insulin spray (Oral-Lyn) in comparison to subcutaneously injected regular human insulin.
Methods: Fifteen patients with type 1 diabetes entered in this open-label single arm study with historical control of the same patients for 8 weeks conducted at the Endocrine and Metabolism Research Institute (EMRI). Some biochemical and hormonal lab tests were taken before and at the end of the study. All patients used Oral-Lyn spray instead of regular insulin in dinner time and peripheral glucose measurements were self-monitored by them via similar type glucometer in four different times included fasting, two hours after breakfast, before dinner and two hours post dinner time blood glucose measures.
Results: This study demonstrated that buccal spray had not serious complications and had the same effects on blood glucose control in comparison with regular insulin injections. Also, the rate of hypoglycemia was decreased to 33.3% at the end of the study from 50% at the beginning. Hemoglobin A1C (HbA1c) values did not show any significant changes throughout the study.
Conclusion: Oral-Lyn provides similar postprandial glucose control and caused lower hypoglycemic episodes when compared to regular insulin injections.