Relationships between serum zinc concentrations and inflammatory intermediate factors, blood glucose, and HbA1c in postmenopausal diabetic women

Abstract

Background: Zinc (Zn( is one of the essential nutrients that its metabolism changes in diabetes. It has been shown that there is a relationship between Zn and both kinds of diabetes [non-insulin-dependent diabetes mellitus (NIDDM) and insulin-dependent diabetes mellitus (IDDM)]. TNF-α and IL-6 relate with BMI and insulin resistance. It seems that there are relationships between Zn and TNF-α, IL-6, blood glucose and HbA1c. The aim of present study was to investigate relationship between serum zinc concentration and inflammatory intermediate, blood glucose and HbA1c in postmenopausal diabetic women.
Methods: We studied 45 diabetic women and 45 healthy women (controls) with BMI 25-30 kg/m2 and aged 45-60 years. Fasting blood sugar (FBS), HbA1c, serum zinc, TNF-α, and IL-6, were determined in the two groups.
Results: There were non significant positive correlations between Zn, IL-6 (r=0.28) and TNF-α
(r= 0.03) and a non significant negative correlation between Zn and FBS (r= -0.06) and HbA1c
(r= -0.07) in diabetic group.
Conclusion: There were not a significant relationship between serum Zn and inflammatory intermediates (TNF-α, IL-6), FBS, and HbA1c in postmenopausal diabetic women.