Journal of Diabetes and Metabolic Disorders 2011. 10( ):15-.

Stem cells: Paradigm and present concepts
Eghbali-Fatourechi Guiti Z , Larijani B


The ultimate goal of stem cell
technology is to generate and expand cells that can be used in human diseases
and regenerative medicine. Diseases that might benefit from cell therapy
include but are not limited to the juvenile diabetes, Parkinson's disease,
myocardial necrosis, spinal cord injury, and nonunion fractures. Two major
sources for human cell therapy have been adult stem (AS) cells and embryonic
stem (ES) cells. Major achievement was made to generate pluripotent stem cells by
inducing pluripotency in cells obtained from patients, and treat patients with patient
reprogrammed cells. In this review we discuss sources and recent
techniques for inducing pluripotency in cells for using in clinic and we will
review concerns regarding potential undesired consequences of cell therapy with
reprogrammed cells.


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