Journal of Diabetes and Metabolic Disorders 2003. 2(0):33-.

ANIMAL MODELS OF DIABETES.
Mohsen EIMEN-SHAHIDI, Hossein HOSSEINZADEH

Abstract


In this article, we review animal models of types 1 and 2 diabetes mellitus.  Models of type 1 diabetes are discussed in two parts, genetic and chemical.  Models of  type 2 diabetes are discussed in four parts - rat and mouse models, dietary induction, and selective breeding.  Models are assessed regarding metabolic disturbances, the condition of the pancreas, long-term complications, and research benefits.


Keywords


diabetes mellitus, animal models, alloxan, streptozotocin,

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