Journal of Diabetes and Metabolic Disorders 2003. 2(0):34-.

EFFECT OF OMEGA-3 FATTY ACIDS ON GLYCAEMIC CONTROL AND LIPID PROFILE IN PATIENTS WITH TYPE 2 DIABETES.
Gholamhossein OMRANI, Zohreh MAZLOOM, Mahmood SAVID, Ali-Ashraf RASHIDI

Abstract


Background: Atherosclerotic complications are one the most common causes of death in patients with type 2 diabetes mellitus.  Epidemiological data indicate that the consumption of omega-3 unsaturated fatty acids (O3FA) leads to a reduction in cardiovascular disorders.  The metabolic effect of this substance in patients with type 2 diabetes is still a matter of debate, however.  The aim of this study was to assess the metabolic effect of O3FA in Iranian diabetic patients.


Methods: 50 diabetic patients (20 men and 30 women; mean age 49±7.3 years) were randomly allocated to either the intervention (diet + fish oil containing O3FA) or the control group (diet alone).  The lipid and glucose levels, blood pressure, and weight of each patient were measured at the beginning of the study.  The duration of the study was 3 months.  The aforementioned parameters were re-assessed at the end of the study.


Results: O3FA consumption was associated with a significant reduction in serum triglyceride levels (p<0.001).  Reductions in weight, fasting blood sugar, and glycosylated haemoglobin were noted in the intervention group but were not statistically significant.  No changes occurred in total cholesterol, HDL, and LDL levels.  The dosage of oral hypoglycaemic agents was unchanged in both groups throughout the study.


Conclusion: O3FA may be recommended for the management of hypertriglyceridaemia.


Keywords


type 2 diabetes, omega-3 unsaturated fatty acids, fish oil, triglyceride, cholesterol,

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