Journal of Diabetes and Metabolic Disorders 2003. 2(0):35-.

THE PRO-ABSORPTIVE EFFECT OF ACANTHOPHYLLUM SQUARROSUM ON INTRA-NASAL INSULIN DELIVERY AND ITS EFFECT ON BLOOD GLUCOSE IN RATS.
Seyyed Abolghassem SAJJADI, Hossein HOSSEINZADEH, Seyyed Ahmad MOHAJERI1 MOHAJERI

Abstract


Objective: To compare the effect on insulin absorption intra-nasally of Acanthophyllum squarrosum (ASQ) compared with Acanthophyllum saponaria (ASA) and sodium cholate (NAC), which have proven pro-absorptive effects.


Methods: The formulation used in this study contained 2IU insulin (per rat), 1% carboxymethylcellulose (CMC) and a pro-absorptive agent at the same concentration.  We assessed the hypoglycaemic effect of each formulation in 5 rats in the fasting state.


Results: There was no significant difference in the pro-absorptive effects of ASQ, ASA, and NAC.  Blood glucose levels 2 hours after administration of insulin, given as a percentage of baseline glucose concentration, were as follows for the three formulations used: ASQ: 36.78±11.06%, ASA: 27.46±2.39%, and NAC: 39.94±14.93%.


Conclusion: Acanthophyllum squarrosum has a significant pro-absorptive effect, comparable to that to Acanthophyllum saponaria.


Keywords


Acanthophyllum squarrosum, Acanthophyllum saponaria, sodium cholate, pro-absorption, insulin, intra-nasal delivery,

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