Journal of Diabetes and Metabolic Disorders8Prevention of Aloe Vera extract on Glucose, serum lipids in fructose-fed adult male rats248248ShahrakiMRMirshekariHShahrakiARShahrakiE20151005Background: Aloe Vera has been introduced as a traditional anti-diabetic agent. The aim of this survey was to evaluate the effect of aqueous extract of Aloe Vera on blood glucose, serum insulin and lipids profiles in fructose-fed male rats.  Methods: The experiment was performed on 45 Wistar-Albino adult male rats that randomly divided into control (A) and four test groups (B, C, D, and E). Control group was fed with water, but test groups took fructose-enriched water (10%, w/v) and received 0, 100, 150 and 200mg/Kg of Aloe Vera aqueous extract, respectively for 4 weeks. At the end of study, animals were anesthetized, sacrificed and blood samples were collected.  Serum glucose, insulin and lipid levels were measured. Obtained data were analyzed by SPSS software, via ANOVA, Tukey and Chi-square statistical tests. Results were expressed as mean±SE. Statistical difference were recognized significant by P<0.05. Results: Results revealed that serum glucose and insulin levels were significantly decreased in group E but HDL value in groups D and E were significantly increased, compared with those of the group B. In addition, water consumption in groups D and E were significantly decreased but food intake was significantly increased just in group E in comparison with those of group B.  Conclusion: The results obtained from this survey showed that Aloe Vera aqueous extract affects serum blood sugar, insulin and lipids profile in fructose-fed male rats. Further studies are warranted to elucidate precise involved mechanisms.https://jdmd.tums.ac.ir/index.php/jdmd/article/view/248https://jdmd.tums.ac.ir/index.php/jdmd/article/download/248/18