Journal of Diabetes and Metabolic Disorders20THE PRO-ABSORPTIVE EFFECT OF ACANTHOPHYLLUM SQUARROSUM ON INTRA-NASAL INSULIN DELIVERY AND ITS EFFECT ON BLOOD GLUCOSE IN RATS.3131Seyyed AbolghassemSAJJADIHosseinHOSSEINZADEHSeyyed Ahmad MOHAJERI1MOHAJERI20151005Objective: To compare the effect on insulin absorption intra-nasally of Acanthophyllum squarrosum (ASQ) compared with Acanthophyllum saponaria (ASA) and sodium cholate (NAC), which have proven pro-absorptive effects. Methods: The formulation used in this study contained 2IU insulin (per rat), 1% carboxymethylcellulose (CMC) and a pro-absorptive agent at the same concentration.  We assessed the hypoglycaemic effect of each formulation in 5 rats in the fasting state. Results: There was no significant difference in the pro-absorptive effects of ASQ, ASA, and NAC.  Blood glucose levels 2 hours after administration of insulin, given as a percentage of baseline glucose concentration, were as follows for the three formulations used: ASQ: 36.78±11.06%, ASA: 27.46±2.39%, and NAC: 39.94±14.93%. Conclusion: Acanthophyllum squarrosum has a significant pro-absorptive effect, comparable to that to Acanthophyllum saponaria.https://jdmd.tums.ac.ir/index.php/jdmd/article/view/31