<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE Articles SYSTEM "HBI_DTD">
<Articles><Article><Journal><PublisherName></PublisherName><JournalTitle>Journal of Diabetes and Metabolic Disorders</JournalTitle><Volume>1</Volume><Issue>0</Issue></Journal><ArticleTitle>PREVALENCE OF DYSLIPIDAEMIA IN DIABETIC PATIENTS ATTENDING THE DIABETES CLINIC AT DOCTOR SHARIATI UNIVERSITY HOSPITAL BETWEEN OCTOBER 1998 AND SEPTEMBER 2000.</ArticleTitle><FirstPage>6</FirstPage><LastPage>6</LastPage><AuthorList><Author><FirstName>Ebrahim</FirstName><LastName>JAVADI</LastName></Author><Author><FirstName>Shahin</FirstName><LastName>YARAHMADI</LastName></Author><Author><FirstName>Bagher</FirstName><LastName>LARIJANI</LastName></Author><Author><FirstName>Ali-Reza</FirstName><LastName>SHAFAEI</LastName></Author><Author><FirstName>Reza</FirstName><LastName>BARADAR-JALILI</LastName></Author></AuthorList><History><PubDate PubStatus="received"><Year>2015</Year><Month>10</Month><Day>05</Day></PubDate></History><Abstract>Introduction: In patients with type 2 diabetes, triglyceride (TG) is usually increased, HDL decreased, and LDL normal.&amp;nbsp; This pattern is associated with an increased risk of coronary heart disease.&amp;nbsp; More recently, dense-particle LDL has been identified as an important risk factor for coronary heart disease.
Methods: 298 patients with type 2 diabetes attending the diabetes clinic at Doctor Shariati University Hospital underwent anthropometric and biochemical assessment.&amp;nbsp; Anthropometric measurements followed WHO criteria.&amp;nbsp; Biochemical indices (apoB100, TG, cholesterol, LDL, LDL particle size, HDL, and apoA1) were measured using standard laboratory methods.&amp;nbsp; One-way ANOVA was used to analyse data with SPSSv6 software.
Results: Mean patient age was 55&amp;plusmn;13.2 years.&amp;nbsp; Mean duration of diabetes was 9.5&amp;plusmn;6.1 years.&amp;nbsp; The majority of patients were moderate to severely overweight.&amp;nbsp; 73.2% of patients had some form of hyperlipidaemia.&amp;nbsp; 20.7% had isolated hypertriglyceridaemia, 21% isolated hypercholesterolaemia, and 31.5% mixed hyperlipidaemia.&amp;nbsp; Mean apoA1 concentration was higher than normal in this group, and mean apoB100 concentration lower.&amp;nbsp; LDL particle size generally followed a small and dense pattern.
Conclusion: This study shows that LDL particles in both men and women with type 2 diabetes undergo both qualitative and quantitative changes.&amp;nbsp; 35.5% of patients had smaller, denser LDL particles than normal.&amp;nbsp; It appears that dyslipidaemia and B-pattern LDL particles are important risk factors for atherosclerosis in this group.</Abstract><web_url>https://jdmd.tums.ac.ir/index.php/jdmd/article/view/6</web_url></Article></Articles>
