Effects of Cigarette Smoking on Postprandial Triglyceride in Healthy Smokers

Abstract

Background: Recent studies revealed that smoking causes metabolic syndrome and insulin resistance which are characterized by increased postprandial triglyceride in smokers compared with nonsmoker people. This study aimed to evaluate the effects of smoking on postprandial triglyceride in healthy smokers.
Methods: In a case-control study 78 participants aged 30-60 years (35 female and 43 male) who referred to the clinics of Khatam-Al-Anbia Hospital, Zahedan and had normal lipid levels and fasting blood sugar were recruited. Of 78 total subjects 39 were smokers and the remaining were non-smokers. Their body mass indices were between 19 to 29.9 kg/m2. Each of these patients consumed 60 g butter (containing 716 kcal energy per 100 grams and 81.06% fat). Then blood triglyceride levels were evaluated one and six hours after consumption. The results were statistically analyzed using T- test and ANOVA.
Results: Triglyceride levels among men and women showed no significant differences (P = 0.403). In both smokers and non-smokers, fasting triglyceride levels were not significantly different, but was significantly different one and six hours after butter consumption (P <0.001). Furthermore, triglyceride levels significantly increased from fasting than one hour and six hours after the butter consumption between smokers and non-smokers (P <0.001).
Conclusion: In this study it was shown that in smokers postprandial triglyceride levels increased more than non-smokers, triglycerides after a meal remained longer in blood and triglyceride clearance delayed as well. The increase in triglyceride levels after a meal and smoking may consider as an important factor in the development of cardiovascular diseases.